OFFLU, the Network of Expertise on Animal Influenza, established by the World Organisation for Animal Health (WOAH) and the Food and Agriculture Organization of the United Nations (FAO), through its Applied Epidemiology Technical Activity, formulated guidelines for HPAI virus risk mitigation in cattle. "This OFFLU Applied Epidemiology Technical Activity document provides practical, evidence-based risk mitigation measures to support countries in making informed decisions to curb the spread of HPAIVs into and within cattle populations, and offers a flexible framework that can be adapted to diverse regional contexts."