This month’s Domestic Swine Disease Monitoring Report brings Porcine Circovirus type 3 PCR data to the SDRS. The addition will help stakeholders to better understand the trends of PCV3 detection, such as the higher positivity of this virus in the adult/sow farm age category. Also, the report brings information about the second consecutive month of increased PRRSV-positivity in the wean-to-market category, raising an alert for sow farms around these positive sites. The PRRSV L1C variant (L1C.5) detection also supports the increased activity in wean-to-market since 62.5% of these sequences were detected in wean-to-market sites in October. For enteric coronaviruses, PEDV positivity in adult/sow farms is above the wean-to-market category for the third consecutive month (August, September, and October). A similar PEDV trend had been seen in 2016 and 2017. For the Influenza A virus, the overall positivity had a moderate increase driven by submissions from adult/sow farms and unknown age categories. In the confirmed tissue diagnosis database, there were alarms for an increased number of PRRSV, Glaesserella parasuis, Streptococcus suis, and Pasteurella multocida between September and October.